Регуляція активності ферментів, Детальна інформація

+ _ \x00F0aaaia\x00F0o\x00BA, eiee NADH+H ia\x00F0aaea\x00BA nai? e - ie \x00B3ioiio aeoeaioi\x00F0o. Oaeei /eiii, iayaia /enei iieaeoe NAD a\x00B3aeiinii iaaaeeea, oi/a a\x00B3i aa\x00F0a o/anoue a aaaaoueio aioo\x00F0\x00B3oiueiee\x00B3oeiieo oa\x00F0iaioaoeaieo \x00F0aaeoe\x00B3yo.

Aeaye\x00B3 oa\x00F0iaioe aeei\x00F0enoiaothoue eioaeoi\x00F0e, eio\x00F0\x00B3 ciaoiaeyoueny a eiiieaen\x00B3 c a\x00B3eeii. Aei ieo a\x00B3aeiinyoueny oae caai\x00B3 i\x00F0inoaoe/i\x00B3 a\x00F0oie, iai\x00F0eeeaae, cae\x00B3ci-n\x00B3\x00F0eiai\x00B3nia a\x00F0oia oa\x00F0aaeienei\x00B3a (a\x00B3eie, yeee aa\x00F0a o/anoue o i\x00F0ioean\x00B3 oioineioaco o \x00F0ineei oeyoii a\x00B3aeiiaeaiiy NADP aei NADPH2), i\x00B3\x00F0eaeienaeueoinoao (a\x00B3oai\x00B3i B2) aai o\x00F0ainai\x00B3iac.

Oaeiae eioa\x00F0iaioe aa\x00F0ooue o/anoue o ia\x00F0aiin\x00B3 niaoeeo\x00B3/ieo o\x00B3i\x00B3/ieo a\x00F0oi. Ine\x00B3eueee e\x00B3ioeaaee oinoaoiee ca’ycie AOO (\x00F0aaoethaaiiy, ca’ycaia c a\x00B3ae\x00F0ie\x00B3cii AOO, aeaoaeueii \x00F0icaeyaea\x00BAoueny aeae\x00B3) eaaei \x00F0ic\x00F0eaa\x00BAoueny c aeae\x00B3eaiiyi a\x00B3eueii? aiaa\x00F0\x00B3?, oea c’\x00BAaeiaiiy \x00BA aoaeoeaiei aeaea\x00F0aeii oinoaoa aeey aaeeei? e\x00B3eueeino\x00B3 \x00F0\x00B3cieo \x00F0aaeoe\x00B3e oinoi\x00F0aethaaiiy. Aaaaoi \x00F0\x00B3ciiiai\x00B3oieo, o\x00B3i\x00B3/ii eaa\x00B3eueieo ca’yce\x00B3a iiaiaeeoueny iiae\x00B3aiei /eiii. Iai\x00F0eeeaae, niaoeeo\x00B3/i\x00B3 iieaeoee - ia\x00F0aiin/eee i\x00B3noyoue aoeaoeeuei\x00B3 aai iaoeeuei\x00B3 a\x00F0oie, c’\x00BAaeiai\x00B3 \x00F0aaeoeaieie ca’yceaie, ui aeicaiey\x00BA oeei a\x00F0oiai eaaei ia\x00F0aoiaeeoe ia \x00B3io\x00B3 iieaeoee. Iaeia e oa naia iieaeoea - ia\x00F0aiin/ee ia\x00F0\x00B3aeei aa\x00F0a o/anoue o aaaaoueio \x00F0\x00B3cieo \x00F0aaeoe\x00B3yo a\x00B3ineioaco, aeey i\x00F0ioiaeaeaiiy yeeo iaiao\x00B3aeia iayai\x00B3noue ?o niaoeeo\x00B3/ieo \x00F0aaeoe\x00B3eiicaeaoieo a\x00F0oi.

I\x00F0eeeaaeii oaeiai eioa\x00F0iaioa - ia\x00F0aiin/eea iiaea neoaoaaoe aoeaoeeeioa\x00F0iaio A (aoeaoee - NiA), ui ooai\x00F0th\x00BAoueny i\x00B3ae /an \x00F0icuaieaiiy aetheice. A\x00B3i ia\x00F0aiineoue aoeaoeeueio a\x00F0oio, i\x00F0e\x00BAaeiaio aei iueiai eaa\x00B3eueiei o\x00B3iao\x00B3\x00F0iei ca’yceii.

Oey aoeaoeeueia a\x00F0oia eaaei ia\x00F0aoiaeeoue ia \x00B3ioo iieaeoeo, oaeo, iai\x00F0eeeaae, ye iieaeoea aee\x00F0ii? eeneioe. \x00B2ioee i\x00F0eeeaae, ui caneoaiao\x00BA ia oaaao - oea a\x00B3ioei, yeee ia\x00F0aiineoue a aaaaoueio \x00F0aaeoe\x00B3yo a\x00B3ineioaco

_ ea\x00F0aieneeueio a\x00F0oio (-- NII ).

A iaaaaeai\x00B3e iine\x00B3aeiaiino\x00B3 \x00F0aaeoe\x00B3e a\x00B3ioei eiaaeaioii ca’ycaiee c oa\x00F0iaioii i\x00B3\x00F0oaao-ea\x00F0aieneeacith. Aeoeaiaaia ea\x00F0aieneeueia a\x00F0oia, ui

_ ooai\x00F0th\x00BAoueny c a\x00B3ea\x00F0aiiao-\x00B3iia (HCO3 ), ca’yco\x00BAoueny c a\x00B3ioeiii a \x00F0aaeoe\x00B3?, ui i\x00F0io\x00B3ea\x00BA ca \x00F0aooiie aia\x00F0a\x00B3?, aeae\x00B3eaii? i\x00B3ae /an a\x00B3ae\x00F0ie\x00B3co AOO. Iio\x00B3i ea\x00F0aieneeueia a\x00F0oia ia\x00F0aiineoueny aei iaoeeueii? a\x00F0oie a\x00F0oie i\x00B3\x00F0oaaoo c ooai\x00F0aiiyi ienaeiaoeaoaoa.

Ieae/a iaaaaeai\x00B3 aeaye\x00B3 eioa\x00F0iaioe, ui aa\x00F0ooue o/anoue a \x00F0aaeoe\x00B3yo ia\x00F0aiino o\x00B3i\x00B3/ieo a\x00F0oi.

Eioa\x00F0iaio A\x00F0oia, ui ia\x00F0aiineoueny

AOO oinoaoia

NADH, NADPH _ aiaeaiue + a (a\x00B3ae\x00F0eae-\x00B3ii)

CoA aoeaoeeueia

A\x00B3ioei ea\x00F0aieneeueia

S - Aaeaiiceeiaoeii\x00B3i iaoeeueia



Aeaye\x00B3 eioa\x00F0iaioe iiaeooue aooe iano\x00B3eueee i\x00B3oeii ca’ycaieie c a\x00B3eeiaith iieaeoeith oa\x00F0iaioa, ui oaeoe/ii \x00BA ?? /anoeiith. sse i\x00F0eeeaae iiaeia iaaanoe aaie, ui i\x00B3noyoue a nia\x00B3 cae\x00B3ci, a iieaeoe\x00B3 aaiiaeia\x00B3ia aai oeeoio\x00F0ii\x00B3a ; o\x00B3ai\x00B3ii\x00B3\x00F0ioinoao o oa\x00F0iaio\x00B3a, ui aa\x00F0ooue o/anoue a ia\x00F0aiin\x00B3 ea\x00F0aieneeueii? a\x00F0oie. A i\x00F0ioean\x00B3 aaiethoe\x00B3? eiaeai eioa\x00F0iaio aoa a\x00B3ae\x00B3a\x00F0aiee ca iaaiith iciaeith o\x00B3i\x00B3/ii? aeoeaiino\x00B3, yeo a\x00B3i i\x00F0iyaey\x00BA a eiiieaen\x00B3 c a\x00B3eeii. Aeineoue /anoi eioa\x00F0iaioaie \x00BA aeoaea neeaaei\x00B3 i\x00F0aai\x00B3/i\x00B3 iieaeoee, o\x00B3i\x00B3/i\x00B3 yeino\x00B3 yeeo a eiiieaen\x00B3 c a\x00B3eeii ia caaaeaee c\x00F0icoi\x00B3e\x00B3 a aeaoaeyo. E\x00F0\x00B3i \x00F0aaeoe\x00B3eii caeaoiiai oeaio\x00F0o aei neeaaeo eioa\x00F0iaio\x00B3a ia\x00F0\x00B3aeei aoiaeyoue caeeoee, ui ca’ycothoue ?o c a\x00B3aeiia\x00B3aeieie a\x00B3eeaie.

\x00D0IEUe AOO O \x00D0IAIO\x00B2 OA\x00D0IAIO\x00B2A

AEeaa ee\x00B3oeia \x00BA aeaeaea a\x00B3ae \x00F0\x00B3aiiaaae o\x00B3i\x00B3/ia nenoaia ; aaeaea iaaeeaeaiiy aeeai? nenoaie aei \x00F0\x00B3aiiaaae icia/a\x00BA ?? \x00F0iciaae \x00B3 nia\x00F0oue. I\x00F0iaeoeo eiaeiiai oa\x00F0iaioa cae/aeii oaeaeei aeo\x00F0a/a\x00BAoueny, ine\x00B3eueee aeei\x00F0enoiao\x00BAoueny a yeino\x00B3 noano\x00F0aoa \x00B3ioei oa\x00F0iaioii aeaiiai iaoaaie\x00B3/iiai oeyoo. Ua a\x00B3eueo aaaeeeai, ui aaeeea e\x00B3euee\x00B3noue oa\x00F0iaioaoeaieo \x00F0aaeoe\x00B3e ca’ycaia c \x00F0icuaieaiiyi AOO ia AAeO oa iai\x00F0aai\x00B3/iee oinoao. Uia oea aoei iiaeeeaei, ioe AOO a naith /a\x00F0ao iiaeiai i\x00B3aeo\x00F0eioaaoenue ia \x00F0\x00B3ai\x00B3, aeaeaeiio a\x00B3ae \x00F0\x00B3aiiaaae, oae uia a\x00B3aeiioaiiy eiioeaio\x00F0aoe\x00B3? AOO aei eiioeaio\x00F0aoe\x00B3? i\x00F0iaeoeo\x00B3a eiai a\x00B3ae\x00F0ie\x00B3co aoei aenieei. Oaeei /eiii, ioe AOO a\x00B3ae\x00B3a\x00F0a\x00BA \x00F0ieue ‘aeoioeyoi\x00F0a’, ui i\x00B3aeo\x00F0eio\x00BA iino\x00B3eiee ia\x00F0ai\x00B3n a ee\x00B3oei\x00B3 aia\x00F0a\x00B3? oa aoii\x00B3a ii iaoaaie\x00B3/iei oeyoai, ui aecia/athoueny i\x00F0enooi\x00B3ie oa\x00F0iaioaie.

Ioaea, \x00F0icaeyiaii i\x00F0ioean a\x00B3ae\x00F0ie\x00B3co AOO \x00B3 eiai aieea ia \x00F0iaioo oa\x00F0iaio\x00B3a. Oya\x00B3ii nia\x00B3 oeiiaee a\x00B3ineioaoe/iee i\x00F0ioean, i\x00F0e yeiio aeaa iiiiia\x00F0e - A oa A - iiaeii\x00B3 ia’\x00BAaeiaoenue i\x00B3ae niaith a \x00F0aaeoe\x00B3? aeaa\x00B3ae\x00F0aoaoe\x00B3? (?? oaeiae iaceaathoue eiiaeainaoe\x00B3\x00BAth), ui noi\x00F0iaiaeaeo\x00BAoueny aeae\x00B3eaiiyi aiaee :

A - I + A - II — AA + I2I

Cai\x00F0ioiy \x00F0aaeoe\x00B3y, yeo iaceaathoue a\x00B3ae\x00F0ie\x00B3cii, a ye\x00B3e iieaeoea aiaee \x00F0oeio\x00BA eiaaeaioii ca’ycaio niieoeo A - A, iaeaea caaaeaee aoaea aia\x00F0aaoe/ii aea\x00B3aeiith. Oea ia\x00BA i\x00B3noea, iai\x00F0eeeaae, i\x00F0e a\x00B3ae\x00F0ie\x00B3oe/iiio \x00F0icuaieaii\x00B3 a\x00B3ee\x00B3a, ioeea?iiaeo eeneio \x00B3 iie\x00B3naoa\x00F0eae\x00B3a ia noaiaeeieoe\x00B3.

Caaaeueia no\x00F0aoaa\x00B3y, ca yeith a\x00B3aeaoaa\x00BAoueny ooai\x00F0aiiy ee\x00B3oeie A - A \x00B3c A - I oa A - II, aeeth/a\x00BA a naaa aaaaoinooi\x00B3i/anoo iine\x00B3aeiai\x00B3noue \x00F0aaeoe\x00B3e, a \x00F0acoeueoao\x00B3 yeeo a\x00B3aeaoaa\x00BAoueny ca’ycoaaiiy aia\x00F0aaoe/ii iaaea\x00B3aeiiai neioaco iio\x00F0\x00B3aieo niieoe \x00B3c caaeainiaaiith aea\x00B3aeiith \x00F0aaeoe\x00B3\x00BAth.

Aae\x00F0ie\x00B3co AOO a\x00B3aeiia\x00B3aea\x00BA aaeeea iaaaoeaia aaee/eia ^ G, oiio a\x00B3ae\x00F0ie\x00B3c AOO /anoi a\x00B3ae\x00B3a\x00F0a\x00BA \x00F0ieue aia\x00F0aaoe/ii ni\x00F0eyoeeai? \x00F0aaeoe\x00B3?,caaaeyee ye\x00B3e cae\x00B3eniththoueny aioo\x00F0\x00B3oiueiee\x00B3oeii\x00B3 \x00F0aaeoe\x00B3? a\x00B3ineioaco.

Ia oeyoo a\x00B3ae A - I oa A - II aei A - A, iia’ycaiiio c a\x00B3ae\x00F0ie\x00B3cii AOO, aia\x00F0a\x00B3y a\x00B3ae\x00F0ie\x00B3co nii/aoeo ia\x00F0aaiaeeoue A - II a aenieiaia\x00F0aaoe/io i\x00F0ii\x00B3aeio niieoeo, yea iio\x00B3i aaciina\x00F0aaeiuei \x00F0aaao\x00BA c A - I, ooai\x00F0thth/e A - A. Iaei\x00F0ino\x00B3oee iaoai\x00B3ci aeaiiai i\x00F0ioeano aeeth/a\x00BA a naaa ia\x00F0ai\x00B3n oinoaoa a\x00B3ae AOO aei A - II c ooai\x00F0aiiyi A - I\x00D0I3, aai A - I - \x00D0, i\x00F0e/iio a oeueiio aeiaaeeo noia\x00F0ia \x00F0aaeoe\x00B3y a\x00B3aeaoaa\x00BAoueny eeoa o aea\x00B3 noaae\x00B3?:

1) A - II + AOO — A - I - \x00D0 + AAeO

2) A - I + A - I - \x00D0 — A - A + \x00D0

Ine\x00B3eueee i\x00F0ii\x00B3aeia niieoea A - I - \x00D0, ui ooai\x00F0th\x00BAoueny a i\x00F0ioean\x00B3 \x00F0aaeoe\x00B3?, iio\x00B3i ciiao \x00F0oeio\x00BAoueny, noia\x00F0i\x00B3 \x00F0aaeoe\x00B3? iiaeia iienaoe ca aeiiiiiaith ianooiieo \x00F0\x00B3aiyiue :

A- I + A - II — A - A oa AOO — AAeO + \x00D0

Ia\x00F0oa, aia\x00F0aaoe/ii iaaea\x00B3aeia \x00F0aaeoe\x00B3y, aeyaey\x00BAoueny iiaeeeaith oiio, ui aiia ca’ycaia c ae\x00F0oaith, aia\x00F0aaoe/ii aea\x00B3aeiith \x00F0aaeoe\x00B3\x00BAth (a\x00B3ae\x00F0ie\x00B3c AOO). I\x00F0eeeaaeii ca’ycaieo a\x00B3ineioaoe/ieo \x00F0aaeoe\x00B3e iiae\x00B3aiiai oeio iiaea aooe neioac ai\x00B3iieeneioe aeooai\x00B3ia.